منابع مشابه
No "bias" toward the null hypothesis in most conventional multipoint nonparametric linkage analyses.
To the Editor: We would like to comment on the Schork and Green-wood (2004) article dealing with the inherent " bias " toward the null hypothesis in the context of nonpara-metric linkage analysis. The authors point out that, in certain situations, a loss of evidence for linkage can result from the practice of assigning expected allele-sharing values to affected relative pairs that are uninforma...
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In this research project, the nitrito nitro isomerization of [Co (NH3)5No2]F2 complex has been studied. Isomerization of this complex in the solid state follows a first order kinetics. The rate of isomerization at different temperatures was determined using a Fourier Transform Lnfrared Spectrophotometer. ? and ? are calculated at 298 K. The infrared, visible and ultraviolet spectra of th...
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one of the most important goals for researchers in the clinic is to try to find newer and more effective ways to diagnose and cure the diseases. these clinical advances can create new points of view in other sciences and their combination with basic sciences such as statistics can improve these researches. in statistical genetics, linkage analysis is a way of finding the exact locus of a diseas...
متن کاملLinkage and Autocorrelation Cause Feature Selection Bias in Relational Learning
Two common characteristics of relational data sets — concentrated linkage and relational autocorrelation — can cause learning algorithms to be strongly biased toward certain features, irrespective of their predictive power. We identify these characteristics, define quantitative measures of their severity, and explain how they produce this bias. We show how linkage and autocorrelation affect a r...
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Two common characteristics of relational data sets — concentrated linkage and relational auto-correlation — can cause traditional methods of evaluation to greatly overestimate the accuracy of induced models on test sets. We identify these characteristics, define quantitative measures of their severity, and explain how they produce this bias. We show how linkage and autocorrelation affect estima...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2004
ISSN: 0002-9297
DOI: 10.1086/424757